Causes, consequences and intervention

Over the past years, fundamental and translational biomedical research have identified a wealth of disease-related molecular mechanisms. The contemporary knowledge, although still far from complete,  has resulted in different approaches trying to correct the cellular consequences of mitochondrial dysfunction ranging from small molecules towards gene therapy. Research in my group studies the consequences of genetic and environmental mitochondrial failure at all level of complexities from single cell studies up to studies in patients and translates these observations into potential new intervention options. Current focus is on genetic defects of the oxidative phosphorylation system and genetic forms of Parkinson disease.

Recent publications

  1. Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy.Iannetti, E.F., Smeitink, J.A.M., Beyrath, J., Willems, P.H.G.M., Koopman, W.J.H. Nature Protoc. 11:1693-1710.

  2. Mitochondrial disorders in children: toward development of small-molecule treatment strategies. Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA. EMBO Mol Med. 2016 Mar 7. pii: e201506131. doi: 10.15252/emmm.201506131. [Epub ahead of print] Review. PubMed PMID: 26951622.

  3. Toward high-content screening of mitochondrial morphology and membrane potential in living cells. Iannetti EF, Willems P, Pellegrini M, Beyrath J, Smeitink J, Blanchet L, Koopman WJ. Int J Biochem Cell Biol. 2015 Feb 8. pii:S1357-2725(15)00030-8.

  4. Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics. Foriel S, Willems P, Smeitink J, Schenck A, Beyrath J. Int J Biochem Cell Biol. 2015 Feb 7. pii: S1357-2725(15)00034-5.

  5. Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ. Sci Rep. 2015 Jan 26;5:8035.